Gold Member Since 2016
Nanjing Bangnuo Biotechnology Co., Ltd.

Genistein, Genistein Powders, Anti - Tumor Genistein manufacturer / supplier in China, offering Natural Gorse Root Plant Extract Powder Anti Tumor CAS 446-72-0 Genistein, USP32 Local Anesthetics CAS 94-24-6 Tetracaine as Antipruritic, Pain and Fever Reduction Pharmaceutical Intermedaite CAS 103-90-2 Paracetamol and so on.

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Natural Gorse Root Plant Extract Powder Anti Tumor CAS 446-72-0 Genistein

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(g)
10-99 100-999 1,000+
FOB Unit Price: US $1 US $0.8 US $0.5
Purchase Qty. (g) FOB Unit Price
10-99 US $1
100-999 US $0.8
1,000+ US $0.5
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Production Capacity: 2000kg/Month
Transport Package: 1kg/Foil Bag
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: 446-72-0
  • Customized: Non-Customized
  • Suitable for: Elderly, Children, Adult
  • Purity: >99%
  • CAS: 446-72-0
  • M.W.: 270.24
  • Specification: 25kg/drum
  • HS Code: 3001200010
  • Powder: Yes
  • Certification: GMP, ISO 9001, USP, BP, SGS, Kosher
  • State: Solid
  • Alias: Genistein
  • M.F.: C15h10o5
  • Trademark: NJBN STEROID
  • Origin: Made in China
Product Description
Natural Gorse Root Plant Extract Powder Anti Tumor Genistein CAS 446-72-0


Product Name: Genistein 
Synonyms: 4',5,7-trihydroxy-isoflavon;5,7-dihydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;c.i.75610;differenola;genistein(synthetic);genisteol;genisterin;prunetol 
CAS: 446-72-0
MF: C15H10O5 
MW: 270.24 
EINECS: 207-174-9
Product Categories: pharmacetical;Biochemistry;Flavonoids;Natural Plant Extract;The group of Daidzin;Inhibitors;Tyrosine Kinase Inhibitors;Protein Kinase;Signalling;Plant extract;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;inhibitor
Melting point : 297-298 °C
Storage temp. : Keep in room temperature .
Chemical Properties : Yellow Crystalline Solid 
Usage : Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol .
Usage : Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. 
Usage : cytotoxic inhibitor of tyrosine kinase and topoisomerase II kinase .


Genistein Description 

Genistein is one of the most abundant isoflavones in soy and is one of several known isoflavones. Isoflavones compounds, such as genistein and daidzein, are found in a number of plants, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Because of its similar structure to that of human estrogen it is also called a phytoestrogen. Genistein is a natural bioactive compound derived from legumes and has drawn because of its potentially beneficial effects on some human degenerative diseases. It has a weak estrogenic effect and is a well-known non-specific tyrosine kinase inhibitor at pharmacological doses .

Genistein is a soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. In adult animals, dietary genistein has chemopreventive effects on breast, prostate, and other endocrine-dependent tumors . 


Health Benefits Estrogenic effect

The estrogenic activity of genistein has been confirmed in many studies. Of all the isoflavones, genistein has the strongest estrogenic activity. The estrogenic effect of genistein may explain its protective action against osteoporosis and its possible effect on body weight reductions. Genistein is also used to ease menopause symptoms, such as hot flushes .


Antioxidant

Genistein is a strong antioxidant. Genistein removes damaging free radicals and reduces lipid peroxidation. Genistein increases the activity of other antioxidant enzymes such as glutathione peroxidase, superoxide dismutase and glutathione reductase. Studies have shown that genistein can also influence the growth of cells which are not hormone-dependent .


Anticancer

Genistein seems to reduce the risk for some hormone related cancers, principally breast cancer and prostate cancer. Epidemiological studies show that consumption of isoflavones may protect against breast and prostate cancer. High dietary intake of soy products China and Japan are linked with low incidence of these cancers. There are lots of theories to explain the anti-cancer action of genistein: inhibition of angiogenesis, inhibition of tyrosine kinases, antioxidant property, and anti-estrogen action (it is known that estrogen increases risk for certain cancers). Genistein binds with estrogen receptors, preventing the estrogen from binding and initiating cancer growth.


Heart health

Many in-vitro tests have demonstrated that genistein inhibits cellular cholesterol synthesis and cholesterol esterification. Genistein also reduces fatty acid oxidation and exerts lipid lowering effect. Only oxidized LDL cholesterol is absorbed by the arterial cells and prevention of this oxidation will reduce the risk for arteriosclerosis. Gensistein prevents the formation of hearth attacks and strokes by acting as anticlotting agent .


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Competitive advantages:

As a pharmaceutical manufacturer, Nanjing Bangnuo Biotechnology Co., Ltd. specializes in steroid raw material and pharmaceutical raw materials. Over the years, we have been committed to provide the top cost-effective products and services to our customers.

Our products have been approved by many organizations and institutions, such as ISO9001 and SGS, etc. And our products have been exported to all over the world. The products can be served in gym fields, athletes fields and medical institutions, etc. 

Discreet package will be adopted to ensure the delivery safety.

Shipping: Within 24 hours after receiving the payment by express delivery (DHL, TNT, FedEx, HKEMS, UPS, EMS, etc.)

Payment Terms: T/T, West Union, Money Gram and Bitcoin.

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