Gold Member Since 2016
Nanjing Bangnuo Biotechnology Co., Ltd.

  Isotretinoin , Skin Care, Antibiotics manufacturer / supplier in China, offering Skin Care Pharmaceutical Powders 4759-48-2 Isotretinoin, Anabolic Steroid Powder CAS 2590-41-2 Dehydronandrolone Acetate, Anti-Inflammatory Pharmaceutical Raw Material CAS 104987-11-3 Tacrolimus and so on.

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Skin Care Pharmaceutical Powders 4759-48-2 Isotretinoin

Purchase Qty.:
(g)
100-999 1,000+
FOB Unit Price: US $2 US $1.5
Purchase Qty. (g) FOB Unit Price
100-999 US $2
1,000+ US $1.5
Get Latest Price
Production Capacity: 800kg/Month
Transport Package: 1kg/Foil Bag
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: 4759-48-2
  • Customized: Non-Customized
  • Suitable for: Elderly, Children, Adult
  • Purity: >99%
  • CAS: 4759-48-2
  • Specification: 25kg/drum
  • HS Code: 3003201600
  • Powder: Yes
  • Certification: GMP, ISO 9001, USP, BP
  • State: Powders
  • Alias: Isotretinoin
  • Trademark: NJBN
  • Origin: Made in China
Product Description
Skin Care Pharmaceutical Powders 4759-48-2 Isotretinoin 

Isotretinoin 
Isotretinoin Synonyms: 13-cis-ra;13-cis-retinoicaci;13-ra;Isoretinoin;isotrex;neovitaminaacid;ro-4-3780 
Isotretinoin CAS: 4759-48-2 
Isotretinoin MF: C20H28O2 
Isotretinoin MW: 300.44 
Isotretinoin EINECS: 225-296-0 
Product Categories: Antibiotics;Organic acids;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;API;BUSPAR;Other APIs;intermediates 
MP  172-175 °C(lit.)
Storage temp.  −20°C
Water Solubility  insoluble 
Stability: Stable, but probably air and light sensitive. Combustible. Incompatible with strong oxidizing agents. 
Chemical Properties Yellow-Orange Crystalline Powder 
Usage Used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin. 
Usage 5HT1a receptor agonist, anxiolytic 

Usage :

Isotretinoin belongs to the first generation of vitamin A acid. It is a stereoisomer of all-trans vitamin A acid. Oral administration has an anti-oil effect which has special effect on severe acne. The mechanism is as follows: 

It can reduce sebaceous gland and inhibit the activity of sebaceous gland, reducing the effect of secretion of the sebaceous glands, thus inhibiting the growth of Propionibacterium which relies on lipid environment. 

It has an anti-keratosis effect, can inhibit the excess proliferation of epidermal and promote its differentiation. It also reduces the keratosis of hair follicles and the catheter of sebaceous glands.

It can also affect the function of lymphocytes and monocytes, and inhibit the chemotaxis of neutrophil, and thus having anti-inflammatory activity.

It can exert its therapeutic effect by selectively binding Vitamin A acid nuclear receptors. It can inhibit the proliferation of acne rod bacilli. Moreover it has effects of immunity stimulation at low doses, but has immunity suppression effect at high doses.

It can inhibit the biogenesis of collagenase and gelatinase in the skin, and can also inhibit the activity of ornithine decarboxylase. Owing to the major role of ornithine decarboxylase in inducing skin mutations, so isotretinoin can also suppress tumorigenesis.

When subjects to topical administration, it has a similar mechanism of action as vitamin A acid which induces the proliferation of epidermal cell, promotes the differentiation of epidermal cell granular layer into the stratum corneum. It can also regulate the horny plug occurring during some abnormal cornification processes of Hair follicle sebaceous epithelium, and thus playing a therapeutic role.

 
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